H Ozaki1, JP Loenneke, RS Thiebaud, T Abe
RESUMO:
Cycle training is widely performed as a major part of any exercise program seeking to improve aerobic capacity and cardiovascular health. However, the effect of cycle training on muscle size and strength gain still requires further insight, even though it is known that professional cyclists display larger muscle size compared to controls. Therefore, the purpose of this review is to discuss the effects of cycle training on muscle size and strength of the lower extremity and the possible mechanisms for increasing muscle size with cycle training. It is plausible that cycle training requires a longer period to significantly increase muscle size compared to typical resistance training due to a much slower hypertrophy rate
Roberta Sartori, Vanina Romanello & Marco Sandri
RESUMO:
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence general metabolism, locomotion, eating and respiration. Therefore, it is not surprising that excessive muscle loss is a bad prognostic index of a variety of diseases ranging from cancer, organ failure, infections and unhealthy ageing
Felipe Damas, Stuart M. Phillips, Cleiton A. Libardi, Felipe C. Vechin1, Manoel E. Lixandrao, Paulo R. Jannig1, Luiz A. R. Costa1, Aline V. Bac
RESUMO:
Skeletal muscle hypertrophy is one of the main outcomes of resistance training (RT), but how hypertrophy is modulated and the mechanisms regulating it are still unknown. To investigate how muscle hypertrophy is modulated through RT, we measured day-to-day integrated myofibrillar protein synthesis (MyoPS) using deuterium oxide and assessed muscle damage at the beginning (T1), at 3 weeks (T2) and at 10 weeks of RT (T3).
Alan L. Kaplana, Jim C. Hub, Abraham Morgentalerc, John P. Mulhalld, Claude C. Schulmane, and Francesco Montorsif
RESUMO:
The use of testosterone therapy in men with prostate cancer was previously contraindicated, although recent data challenge this axiom. Over the past 2 decades, there has been a dramatic paradigm shift in beliefs, attitude, and treatment of testosterone deficiency in men with prostate cancer.
Michael Schulster, Aaron M Bernie, Ranjith Ramasamy
RESUMO:
Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis.
Tetsuya Hirono, Tome Ikezoe, Masashi Taniguchi, Hiroki Tanaka, Junya Saeki, Masahide Yagi, Jun Umehara, and Noriaki Ichihashi
RESUMO:
Hirono, T, Ikezoe, T, Taniguchi, M, Tanaka, H, Saeki, J, Yagi, M, Umehara, J, and Ichihashi, N. Relationship between muscle swelling and hypertrophy induced by resistance training. J Strength Cond Res 36(2): 359–364, 2022—Muscle swelling immediately after resistance exercise may be induced by metabolic stress. The accumulation of metabolic stress is considered to promote muscle hypertrophy after several weeks of resistance training (RT).
Emily E. Howard…
RESUMO:
Testosterone supplementation during energy deficit promotes whole body lean mass accretion, but the mechanisms underlying that effect remain unclear. To elucidate those mechanisms, skeletal muscle molecular adaptations were assessed from muscle biopsies collected before, 1 h, and 6 h after exercise and a mixed meal (40 g protein, 1 h postexercise) following 14 days of weight maintenance (WM) and 28 days of an exercise- and diet-induced 55% energy deficit (ED) in 50 physically active nonobese men treated with 200 mg testosterone enanthate/wk (TEST) or placebo (PLA) during the ED.
James G. Tidball
RESUMO:
Modified muscle use or injury can produce a stereotypic inflammatory response in which neutrophils rapidly invade, followed by macrophages. This inflammatory response coincides with muscle repair, regeneration, and growth, which involve activation and proliferation of satellite cells, followed by their terminal differentiation.
Daniel Rooks, PhD; Therese Swan, PharmD; Budhaditya Goswami, MStat; Lee Anne Filosa, PharmD; Ola Bunte, MSc; Nicolas Panchaud, PhD; Laura A. Coleman, PhD; Ram R. Miller, MD, CM; Elisa Garcia Garayoa, PhD; Jens Praestgaard, PhD; Robert G. Perry, MD; Chris Recknor, MD; Charles M. Fogarty, MD; Hidenori Arai, MD, PhD; LiangKung Chen, MD, PhD; Jun Hashimoto, MD, PhD; Yoon-Sok Chung, MD, PhD; John Vissing, MD, DMSci; Didier Laurent, PhD; Olivier Petricoul, PhD; Sarah Hemsley, BSc; Estelle Lach-Trifilieff, PhD; Dimitris A. Papanicolaou, MD; Ronenn Roubenoff, MD, MHS
RESUMO:
The potential benefit of novel skeletal muscle anabolic agents to improve physical function in people with sarcopenia and other muscle wasting diseases is unknown.
Donna H. Ryan*
Pennington Biomedical Research Center, Baton Rouge, LA, USA
RESUMO:
There is a new generation of antiobesity drugs in development or just arriving on the scene. First, setmelanotide
has been approved for three of the ultrarare genetic conditions that cause obesity—pro-opiomelanocortin deficiency, proprotein convertase subtilisin and kexin type 1 (an important enzyme in the melanocortin pathway)
and leptin receptor deficiency.
RESUMO:
A glutamina é o aminoácido livre mais abundante no plasma e no tecido muscular. Nutricionalmente é classificada como um aminoácido não essencial, uma vez que pode ser sintetizada pelo organismo a partir de outros aminoácidos. A glutamina está envolvida em diferentes funções, tais como a proliferação e desenvolvimento de células, o balanço acidobásico, o transporte da amônia entre os tecidos, a doação de esqueletos de carbono para a gliconeogênese, a participação no sistema antioxidante e outras.
HOWARD J. TATUM, M.D., PH.D.
ELSIMAR M. COUTINHO, M.D.
J. ADEODATO FILHO, M.D.
ANA RITA S. SANT’ANNA, D.D.S.
New York, New York, and Bahia, Brazil
RESUMO:
Capsules of silicone rubber each containing approximately 18 mg. of megestrol acetate (MA) were implanted subcutaneously in 24 women. During the first portion of this study the patients were wearing IUCD’s. Four different dosage groups were studied. Pregnancies occurred in patients who received one or two implants but not in those bearing either four or six capsules. Clinical, histologic, and cytologic data suggested that ovulation was not suppressed by four or fewer implants. The data suggested that there was frequent inhibition of ovulation in the patients bearing six implants. The patients’ subjective reaction to this new technique was favorable. There were no local or systemic complications attributable to the implants. It is suggested that fewer than six implants of this size may provide acceptable long term contraception without the inhibition of ovulation.
Jason Wang , Alice F. Yan 2, Lawrence J. Cheskin and Zumin Shi
RESUMO:
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been highly recommended for glycemic
control and weight reduction. However, evidence has accumulated that GLP-1 RAs treatment is related to an increase in heart rate, which could potentially induce cardiac arrhythmias. This study aims to investigate the association of GLP-1 RAs therapy with incident arrhythmias in diabetic and obese patients.
Sijin Wu, Wenzhao Lu, Zhongli Chen, Yan Dai, Keping Chen* and Shu Zhang
RESUMO:
Low testosterone may be a novel risk factor for prediabetes. We assessed the associations between prediabetes and total serum testosterone (TT), and whether the associations were modified by population characteristics. The data from 5330 adults aged ≥ 20 years, who participated in the 2011–2016 National Health and Nutrition Examination Survey in the United States, were used. Prediabetes was based on fasting plasma glucose, HbA1c, or OGTT. Sociodemographic, obesity, co-morbidities, and lifestyle factors were included in logistic regression models.
Simone Perna, Tariq A. Alalwan, Zahraa Alaali, Tahera Alnashaba, Clara Gasparri, Vittoria Infantino Layla Hammad, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini and Mariangela Rondanelli
RESUMO:
The scientific literature has demonstrated that glutamine is one of the main beneficial
amino acids. It plays an important role in gut microbiota and immunity. This paper provides a
critical overview of experimental studies (in vitro, in vivo, and clinical) investigating the efficacy
of glutamine and its effect on gut microbiota
